Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles / L.Lartigue, K.Oumzil, Y.Guari, J.Larionova, C.Guerin, JL.Montero, V.Barragan-Montero, C.Sangregorio, A.Caneschi, C.Innocenti, T.Kalaivani, P.Arosio, A.Lascialfari. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 11:(2009), pp. 2992-2995. [10.1021/ol900949y]
Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles
SANGREGORIO, CLAUDIO;CANESCHI, ANDREA;C. Innocenti;
2009
Abstract
Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
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