Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles / L.Lartigue;K.Oumzil;Y.Guari;J.Larionova;C.Guerin;JL.Montero;V.Barragan-Montero;C.Sangregorio;A.Caneschi;C.Innocenti;T.Kalaivani;P.Arosio;A.Lascialfari. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 11:(2009), pp. 2992-2995. [10.1021/ol900949y]
Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles
SANGREGORIO, CLAUDIO;CANESCHI, ANDREA;C. Innocenti;
2009
Abstract
Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.
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