Recently, it has been demonstrated that monoallelic PALB2 mutations predispose to familial breast cancer.We investigated the contribution of PALB2 mutations in a set of 132 Italian BRCA1/BRCA2–negative breast cancer families; one truncating PALB2 mutation, c.2257C[T, resulting in p.Arg753X, was identified in a woman and her daughter, with breast cancer diagnosed at 60 and 31 years old, respectively. This study supports the recent observation that PALB2 mutation are present, although infrequently, in familial BRCA1/BRCA2-negative breast cancer cases; moreover, it sustainslatest evidences that some PALB2 mutations are associated with a substantially increased risk of breast cancer.

A PALB2 germline mutation associated with hereditary breast cancer in Italy / L. Papi;A. L. Putignano;C. Congregati;I. Piaceri;I. Zanna;F. Sera;D. Morrone;M. Genuardi;D. Palli. - In: FAMILIAL CANCER. - ISSN 1573-7292. - STAMPA. - 9:(2009), pp. 181-185. [10.1007/s10689-009-9295-z]

A PALB2 germline mutation associated with hereditary breast cancer in Italy.

PAPI, LAURA;PUTIGNANO, ANNA LAURA;PIACERI, IRENE;F. Sera;
2009

Abstract

Recently, it has been demonstrated that monoallelic PALB2 mutations predispose to familial breast cancer.We investigated the contribution of PALB2 mutations in a set of 132 Italian BRCA1/BRCA2–negative breast cancer families; one truncating PALB2 mutation, c.2257C[T, resulting in p.Arg753X, was identified in a woman and her daughter, with breast cancer diagnosed at 60 and 31 years old, respectively. This study supports the recent observation that PALB2 mutation are present, although infrequently, in familial BRCA1/BRCA2-negative breast cancer cases; moreover, it sustainslatest evidences that some PALB2 mutations are associated with a substantially increased risk of breast cancer.
2009
9
181
185
L. Papi;A. L. Putignano;C. Congregati;I. Piaceri;I. Zanna;F. Sera;D. Morrone;M. Genuardi;D. Palli
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/374537
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