Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P<0.05), and specificity 92% versus 86%, respectively for dipyridamole versus dobutamine. In the 38 CAD territories, dipyridamole UR was -4.1±29.4%, and dobutamine UR was -13.1±19.9% (P<0.05). In the 37 no-CAD territories, UR was 34±23.6% for dipyridamole and -0.4±17.8% for dobutamine (P<0.0001). UR difference between CAD versus no-CAD territories was larger using dipyridamole (P<0.0001) than dobutamine (P<0.005). Conclusion. The UR comparison confirms that [99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.

Decreased [99mTc]Sestamibi uptake with dobutamine versus dipyridamole stress. Q J Nucl Med Mol Imaging / R. Sciagrà; O. Zoccarato; G. Bisi; A. Pupi.. - In: THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1824-4785. - STAMPA. - 53:(2009), pp. 671-677.

Decreased [99mTc]Sestamibi uptake with dobutamine versus dipyridamole stress. Q J Nucl Med Mol Imaging.

SCIAGRA', ROBERTO;PUPI, ALBERTO
2009

Abstract

Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P<0.05), and specificity 92% versus 86%, respectively for dipyridamole versus dobutamine. In the 38 CAD territories, dipyridamole UR was -4.1±29.4%, and dobutamine UR was -13.1±19.9% (P<0.05). In the 37 no-CAD territories, UR was 34±23.6% for dipyridamole and -0.4±17.8% for dobutamine (P<0.0001). UR difference between CAD versus no-CAD territories was larger using dipyridamole (P<0.0001) than dobutamine (P<0.005). Conclusion. The UR comparison confirms that [99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.
2009
53
671
677
R. Sciagrà; O. Zoccarato; G. Bisi; A. Pupi.
File in questo prodotto:
File Dimensione Formato  
dipi_dobu.pdf

accesso aperto

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Open Access
Dimensione 112.94 kB
Formato Adobe PDF
112.94 kB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/384430
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact