A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.
One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate / D. Scarpi; E. G. Occhiato; A. Guarna; V. Borzatta. - In: LETTERS IN ORGANIC CHEMISTRY. - ISSN 1570-1786. - STAMPA. - 7:(2010), pp. 311-313.
One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate
SCARPI, DINA;OCCHIATO, ERNESTO GIOVANNI;GUARNA, ANTONIO;
2010
Abstract
A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.
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