Isotopomeric diols by "one pot" Ru-catalyzed homogeneous hydrogenation of dicarboxylic acids.

The ‘‘one-pot” homogeneous hydrogenation of -butyrolactone and succinic or fumaric acid to 1,4-butandiol, have been successfully realized in the presence of the catalytic system [Ru(acac)3]/triphos] [triphos: MeC(CH2PPh2)3]. The influence of some reaction parameters on the regioselectivity and the rate of the reaction were investigated. The study was then extended to the ‘‘one-pot” synthesis of isotopomeric 1,4-butandiols by deuteration of the appropriate substrates in a deuterated solvent. 1,4-butandiol-d8, which was fully characterized, was obtained with 96% yield and 100% isotopomeric selectivity. A mechanism was proposed to rationalize the role of catalyst, solvent and deuterium distribution