This paper reports a number of original thin layer chromatography enantioseparations of closely related ketones and alcohols such as tetralones, indanones, and benzhydrols carried out by elution with aqueous-alcoholic mixtures at different ratios. In order to investigate the structural and substituent effects on chiral recognition of microcrystalline cellulose triacetate, the results were compared with those obtained in previous papers for analogous compounds in similar experimental conditions. Even though the inclusion model of retention of analytes on this chiral stationary phase is confirmed, different and unexpected results were obtained for compounds having very favourable characteristics for resolution.

Structure and substituent effects on retention and chiral resolution of ketones and alcohols on microcrystalline cellulose triacetate plates / L. Lepri; A. Cincinelli; L. Checchini; M. Del Bubba. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - STAMPA. - 71:(2010), pp. 685-694. [10.1365/S10337-010-1508-Y]

Structure and substituent effects on retention and chiral resolution of ketones and alcohols on microcrystalline cellulose triacetate plates

LEPRI, LUCIANO;CINCINELLI, ALESSANDRA;CHECCHINI, LEONARDO;DEL BUBBA, MASSIMO
2010

Abstract

This paper reports a number of original thin layer chromatography enantioseparations of closely related ketones and alcohols such as tetralones, indanones, and benzhydrols carried out by elution with aqueous-alcoholic mixtures at different ratios. In order to investigate the structural and substituent effects on chiral recognition of microcrystalline cellulose triacetate, the results were compared with those obtained in previous papers for analogous compounds in similar experimental conditions. Even though the inclusion model of retention of analytes on this chiral stationary phase is confirmed, different and unexpected results were obtained for compounds having very favourable characteristics for resolution.
2010
71
685
694
L. Lepri; A. Cincinelli; L. Checchini; M. Del Bubba
File in questo prodotto:
File Dimensione Formato  
Chromatographia_2010.pdf

accesso aperto

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Open Access
Dimensione 1.21 MB
Formato Adobe PDF
1.21 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/386239
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 15
social impact