Background and aim: Some studies recently reported a favourable effect for cis-9, trans-11 conjugated linoleic acid (CLA) on plasma lipoprotein profile of healthy subjects. Aim of this crossover intervention study was to evaluate the influence of a short-term dietary intake of a cheese derived from sheep’s milk naturally rich in CLA on several atherosclerotic biomarkers, in comparison with a commercially available cheese. Methods and results: Ten subjects (6 F; 4 M) with a median age of 51.5 followed for 10 weeks a diet containing 200 g/week of cheese naturally rich in CLA (intervention period) and for the same period a diet containing a commercially available cheese of the same quantity (placebo period). Consumption of the dairy product naturally rich in cis-9, trans-11 CLA determined a significant (p < 0.05) reduction in inflammatory parameters such as interleukin-6 (pre: 8.08 1.57 vs. post: 4.58 0.94 pg/mL), interleukin-8 (pre: 45.02 5.82 vs. post: 28.59 2.64 pg/mL), and tumour necrosis factor-a (pre: 53.58 25.67 vs. post: 32.09 17.42 pg/mL) whereas no significant differences in the placebo period were observed. With regard to haemorheological parameters, the test period significantly ameliorated eryth- rocytes’ filtration rate (pre: 7.61 0.71% vs. post: 9.12 0.97%; p Z 0.03) with respect to the placebo period. Moreover, a reduction in the extent of platelet aggregation, induced by arachidonic acid [pre: 87.8 1.76% vs. post: 77.7 3.56%; p Z 0.04] was observed during the test period in comparison with the placebo period. Conclusions: Dietary short-term intake of the tested dairy product naturally rich in cis-9, trans-11 CLA appeared to cause favourable biochemical changes of atherosclerotic markers.

Effects of a dairy product (pecorino cheese) naturally rich in cis-9,trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study / F.Sofi; A.Buccioni; F.Cesari; A.M.Gori; S.Minieri; L.Mannini; A.Casini; G.F.Gensini; R.Abbate; M.Antongiovanni. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - STAMPA. - 20:(2010), pp. 117-124. [10.1016/j.numecd.2009.03.004]

Effects of a dairy product (pecorino cheese) naturally rich in cis-9,trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study

SOFI, FRANCESCO;BUCCIONI, ARIANNA;CESARI, FRANCESCA;GORI, ANNA MARIA;CASINI, ALESSANDRO;GENSINI, GIAN FRANCO;ABBATE, ROSANNA;ANTONGIOVANNI, MAURO
2010

Abstract

Background and aim: Some studies recently reported a favourable effect for cis-9, trans-11 conjugated linoleic acid (CLA) on plasma lipoprotein profile of healthy subjects. Aim of this crossover intervention study was to evaluate the influence of a short-term dietary intake of a cheese derived from sheep’s milk naturally rich in CLA on several atherosclerotic biomarkers, in comparison with a commercially available cheese. Methods and results: Ten subjects (6 F; 4 M) with a median age of 51.5 followed for 10 weeks a diet containing 200 g/week of cheese naturally rich in CLA (intervention period) and for the same period a diet containing a commercially available cheese of the same quantity (placebo period). Consumption of the dairy product naturally rich in cis-9, trans-11 CLA determined a significant (p < 0.05) reduction in inflammatory parameters such as interleukin-6 (pre: 8.08 1.57 vs. post: 4.58 0.94 pg/mL), interleukin-8 (pre: 45.02 5.82 vs. post: 28.59 2.64 pg/mL), and tumour necrosis factor-a (pre: 53.58 25.67 vs. post: 32.09 17.42 pg/mL) whereas no significant differences in the placebo period were observed. With regard to haemorheological parameters, the test period significantly ameliorated eryth- rocytes’ filtration rate (pre: 7.61 0.71% vs. post: 9.12 0.97%; p Z 0.03) with respect to the placebo period. Moreover, a reduction in the extent of platelet aggregation, induced by arachidonic acid [pre: 87.8 1.76% vs. post: 77.7 3.56%; p Z 0.04] was observed during the test period in comparison with the placebo period. Conclusions: Dietary short-term intake of the tested dairy product naturally rich in cis-9, trans-11 CLA appeared to cause favourable biochemical changes of atherosclerotic markers.
2010
20
117
124
F.Sofi; A.Buccioni; F.Cesari; A.M.Gori; S.Minieri; L.Mannini; A.Casini; G.F.Gensini; R.Abbate; M.Antongiovanni
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/386711
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