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EnglishA growing body of evidence implicates low membrane cholesterol in the pathogenesis of Alzheimer’s disease (AD). Here we show that A 42 soluble oligomers accumulate more slowly and in reduced amount at the plasma membranes of PS-1L392V and APPV717I fibroblasts from familial AD (FAD) patients enriched in cholesterol content than at the counterpart membranes. The A 42-induced production of reactive oxygen species (ROS) and the increase in membrane lipoperoxidation were also prevented by high membrane cholesterol, thus resulting in a higher resistance to amyloid toxicity with respect to control fibroblasts. On the other hand, the recruitment of amyloid assemblies to the plasma membrane of cholesterol-depleted fibroblasts was significantly increased, thus triggering an earlier and sharper production of ROS and a higher membrane oxidative injury. These results identify membrane cholesterol as being key to A 42 oligomer accumulation at the cell surfaces and to the following A 42-induced cell death in AD neurons.
Membrane cholesterol enrichment prevents Abeta-induced oxidative stress in Alzheimer's fibroblasts / A. Pensalfini ; M. Zampagni ; G. Liguri ; M. Becatti ; E. Evangelisti ; C. Fiorillo ; S. Bagnoli ; E. Cellini ; B. Nacmias ; S. Sorbi ; C. Cecchi. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - STAMPA. - 32(2011), pp. 210-222. [10.1016/j.neurobiolaging.2009.02.010]
| Titolo: | Membrane cholesterol enrichment prevents Abeta-induced oxidative stress in Alzheimer's fibroblasts. | |
| Autori di Ateneo: | ||
| Autori: | PENSALFINI, ANNA; ZAMPAGNI, MARIAGIOIA; LIGURI, GIANFRANCO; BECATTI, MATTEO; EVANGELISTI, ELISA; FIORILLO, CLAUDIA; BAGNOLI, SILVIA; CELLINI, ELENA; NACMIAS, BENEDETTA; SORBI, SANDRO; CECCHI, CRISTINA | |
| Anno di registrazione: | 2011 | |
| Rivista: | ||
| Volume: | 32 | |
| Pagina iniziale: | 210 | |
| Pagina finale: | 222 | |
| Abstract: | A growing body of evidence implicates low membrane cholesterol in the pathogenesis of Alzheimer’s disease (AD). Here we show that A 42 soluble oligomers accumulate more slowly and in reduced amount at the plasma membranes of PS-1L392V and APPV717I fibroblasts from familial AD (FAD) patients enriched in cholesterol content than at the counterpart membranes. The A 42-induced production of reactive oxygen species (ROS) and the increase in membrane lipoperoxidation were also prevented by high membrane cholesterol, thus resulting in a higher resistance to amyloid toxicity with respect to control fibroblasts. On the other hand, the recruitment of amyloid assemblies to the plasma membrane of cholesterol-depleted fibroblasts was significantly increased, thus triggering an earlier and sharper production of ROS and a higher membrane oxidative injury. These results identify membrane cholesterol as being key to A 42 oligomer accumulation at the cell surfaces and to the following A 42-induced cell death in AD neurons. | |
| Handle: | http://hdl.handle.net/2158/387109 | |
| Appare nelle tipologie: | 1a - Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Membrane cholesterol 2011.pdf | Versione finale referata (Postprint, Accepted manuscript) | Open Access | Accesso pubblicoVisualizza/Apri |
http://hdl.handle.net/2158/387109
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