Classic treatments of osteogenesis imperfecta for children and adults include rehabilitation therapy and orthopedic surgery. New treatments include bisphosphonates. Among them, the effects of intravenous pamidronate have been primarily evaluated in children in several open cohorts. Treatments of adult patients are not established. Several other treatments may have an effect on the fracture rate. However, further studies are needed to demonstrate an effect on fracture rate in children and adult patients. A new approach has been developed to replace mutated genes using mesenchymal stem cells and a construct, which inactivates COL1A1.

Osteogenesis Imperfecta: New Treatment Options / Chevrel G; Cimaz R;. - In: CURRENT RHEUMATOLOGY REPORTS. - ISSN 1523-3774. - STAMPA. - 8(2006), pp. 474-479.

Osteogenesis Imperfecta: New Treatment Options.

CIMAZ, ROLANDO
2006

Abstract

Classic treatments of osteogenesis imperfecta for children and adults include rehabilitation therapy and orthopedic surgery. New treatments include bisphosphonates. Among them, the effects of intravenous pamidronate have been primarily evaluated in children in several open cohorts. Treatments of adult patients are not established. Several other treatments may have an effect on the fracture rate. However, further studies are needed to demonstrate an effect on fracture rate in children and adult patients. A new approach has been developed to replace mutated genes using mesenchymal stem cells and a construct, which inactivates COL1A1.
8
474
479
Chevrel G; Cimaz R;
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/387794
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