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EnglishThe physiology and pathophysiology of the network of interstitial cells of Cajal associated with the deep muscular plexus (ICC-DMP) of the small intestine are still poorly understood. The objectives of the present study were to evaluate the effects of inflammation associated with Trichinella spiralis infection on the ICC-DMP and to correlate loss of function with structural changes in these cells and associated structures. We used immunohistochemistry, electron microscopy, and assessment of distention-inducing electrophysiological parameters in vitro. Damage to ICC-DMP was associated with a loss of distention-induced patterns of electrical activity normally associated with distention-induced peristalsis. Consistently, the timing of recovery of ICC-DMP paralleled the timing of recovery of the distention-induced activity. Nerve varicosities associated with ICC-DMP including cholinergic nerves, assessed by immunoelectron microscopy and whole mount double labeling, paralleled injury to ICC-DMP thus contributing to impaired excitatory innervation of smooth muscle cells. Major additional changes included a remodeling of the inner circular muscle layer, which may affect long-term sensitivity to distention after infection. In conclusion, transient injury to ICC-DMP in response to T. spiralis infection is severe and associated with a complete lack of distention-induced burst-type muscle activity. PMID:16049330 [PubMed - indexed for MEDLINE] PMCID:PMC1603561
Changes in interstitial cells of cajal at the deep muscular plexus are associated with loss of distention-induced burst-type muscle activity in mice infected by Trichinella spiralis / Wang X-Y; Vannucchi MG; Nieuwmeyer F; Ye J; Faussone-Pellegrini MS; Huizinga JD. - In: THE AMERICAN JOURNAL OF PATHOLOGY. - ISSN 0002-9440. - ELETTRONICO. - 167(2005), pp. 437-453.
| Titolo: | Changes in interstitial cells of cajal at the deep muscular plexus are associated with loss of distention-induced burst-type muscle activity in mice infected by Trichinella spiralis | |
| Autori di Ateneo: | ||
| Autori: | Wang X. Y; VANNUCCHI, MARIA; Nieuwmeyer F; Ye J; PELLEGRINI, MARIA SIMONETTA; Huizinga JD | |
| Anno di registrazione: | 2005 | |
| Rivista: | ||
| Volume: | 167 | |
| Pagina iniziale: | 437 | |
| Pagina finale: | 453 | |
| Abstract: | The physiology and pathophysiology of the network of interstitial cells of Cajal associated with the deep muscular plexus (ICC-DMP) of the small intestine are still poorly understood. The objectives of the present study were to evaluate the effects of inflammation associated with Trichinella spiralis infection on the ICC-DMP and to correlate loss of function with structural changes in these cells and associated structures. We used immunohistochemistry, electron microscopy, and assessment of distention-inducing electrophysiological parameters in vitro. Damage to ICC-DMP was associated with a loss of distention-induced patterns of electrical activity normally associated with distention-induced peristalsis. Consistently, the timing of recovery of ICC-DMP paralleled the timing of recovery of the distention-induced activity. Nerve varicosities associated with ICC-DMP including cholinergic nerves, assessed by immunoelectron microscopy and whole mount double labeling, paralleled injury to ICC-DMP thus contributing to impaired excitatory innervation of smooth muscle cells. Major additional changes included a remodeling of the inner circular muscle layer, which may affect long-term sensitivity to distention after infection. In conclusion, transient injury to ICC-DMP in response to T. spiralis infection is severe and associated with a complete lack of distention-induced burst-type muscle activity. PMID:16049330 [PubMed - indexed for MEDLINE] PMCID:PMC1603561 | |
| Handle: | http://hdl.handle.net/2158/388382 | |
| Appare nelle tipologie: | 1a - Articolo su rivista |
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