We present the self-dynamics of protein amino acids of hydrated lysozyme powder around the physiological temperature by means of molecular dynamics simulations. The self-intermediate scattering functions of the amino acid residue center of mass display a logarithmic decay over 3 decades of time, from 2 ps to 2 ns, followed by an exponential alpha relaxation. This kind of slow dynamics resembles the relaxation scenario within the beta-relaxation time range predicted by mode coupling theory in the vicinity of higher-order singularities. These results suggest a strong analogy between the single-particle dynamics of the protein and the dynamics of colloidal, polymeric, and molecular glass-forming liquids.

Logarithmic Decay in Single-Particle Relaxation of Hydrated Lysozyme Powder / M. Lagi; P. Baglioni; SH. Chen. - In: PHYSICAL REVIEW LETTERS. - ISSN 0031-9007. - STAMPA. - 103:(2009), pp. 108102-1-108102-4. [10.1103/PhysRevLett.103.108102]

Logarithmic Decay in Single-Particle Relaxation of Hydrated Lysozyme Powder

LAGI, MARCO;BAGLIONI, PIERO;
2009

Abstract

We present the self-dynamics of protein amino acids of hydrated lysozyme powder around the physiological temperature by means of molecular dynamics simulations. The self-intermediate scattering functions of the amino acid residue center of mass display a logarithmic decay over 3 decades of time, from 2 ps to 2 ns, followed by an exponential alpha relaxation. This kind of slow dynamics resembles the relaxation scenario within the beta-relaxation time range predicted by mode coupling theory in the vicinity of higher-order singularities. These results suggest a strong analogy between the single-particle dynamics of the protein and the dynamics of colloidal, polymeric, and molecular glass-forming liquids.
2009
103
108102-1
108102-4
M. Lagi; P. Baglioni; SH. Chen
File in questo prodotto:
File Dimensione Formato  
PRL-logarithmic-deacy.pdf

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Tutti i diritti riservati
Dimensione 1.12 MB
Formato Adobe PDF
1.12 MB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/389715
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 39
  • ???jsp.display-item.citation.isi??? 40
social impact