P>The characteristics of 1,124 consecutive adults and children with refractory epilepsy attending 11 tertiary referral centers in Italy were investigated at enrollment into a prospective observational study. Among 933 adults (age 16-86 years), the most common syndromes were symptomatic (43.7%) and cryptogenic (39.0%) focal epilepsies, followed by idiopathic (8.1%) and cryptogenic/symptomatic generalized (6.2%) epilepsies. The most common syndrome among 191 children was symptomatic focal epilepsy (35.1%), followed by cryptogenic focal (18.8%), cryptogenic/symptomatic generalized (18.3%), undetermined whether focal or generalized (16.8%), and idiopathic generalized (7.3%). Primarily and secondarily generalized tonic-clonic seizures were reported in 27.8% of adults and 16.8% of children. The most commonly reported etiologies were mesial temporal sclerosis (8.0%) and disorders of cortical development (6.2%) in adults, and disorders of cortical development (14.7%) and nonprogressive encephalopathies (6.8%) in children. More than three-fourths of subjects in both age groups were on antiepileptic drug (AED) polytherapy.
Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy / Alexandre V Jr; Capovilla G; Fattore C; Franco V; Gambardella A; Guerrini R; La Briola F; Ladogana M; Rosati E; Specchio LM; Striano S; Perucca E; on behalf of the SOPHIE Study Group. - In: EPILEPSIA. - ISSN 0013-9580. - STAMPA. - 51 (5):(2010), pp. 921-925. [10.1111/j.1528-1167.2009.02512.x]