A neuropathological characteristic of Alzheimer’s disease is the extracellular accumulation of amyloid beta peptide (Aβ) in neuritic plaques. Recent evidences suggested that soluble Aβ oligomers are the predominant neurotoxic species for neurons. Thus, considerable attention has been paid to discriminate the cytotoxic pathways of Aβ pre-fibrillar aggregates and mature fibrils. We showed that the mechanisms by which Aβ oligomers and fibrils generated reactive oxygen species differ in terms of site of production and kinetics, suggesting the involvement of different intra/extracellular pathways.

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways / G. Cenini; C. Cecchi; A. Pensalfini; S.A. Bonini ; G. Ferrari-Toninelli; G. Liguri; M. Memo; D. Uberti .. - In: AMINO ACIDS. - ISSN 0939-4451. - STAMPA. - 38:(2010), pp. 1101-1106. [10.1007/s00726-009-0319-7]

Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways.

CECCHI, CRISTINA;PENSALFINI, ANNA;LIGURI, GIANFRANCO;
2010

Abstract

A neuropathological characteristic of Alzheimer’s disease is the extracellular accumulation of amyloid beta peptide (Aβ) in neuritic plaques. Recent evidences suggested that soluble Aβ oligomers are the predominant neurotoxic species for neurons. Thus, considerable attention has been paid to discriminate the cytotoxic pathways of Aβ pre-fibrillar aggregates and mature fibrils. We showed that the mechanisms by which Aβ oligomers and fibrils generated reactive oxygen species differ in terms of site of production and kinetics, suggesting the involvement of different intra/extracellular pathways.
38
1101
1106
G. Cenini; C. Cecchi; A. Pensalfini; S.A. Bonini ; G. Ferrari-Toninelli; G. Liguri; M. Memo; D. Uberti .
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/392474
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