With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours. Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer. Radiotherapy may play a role in the onset of such lesions. We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field. Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations.
Synchronous Angiosarcoma, Melanoma and Morphea of the Breast Skin 14 years After Radiotherapy for Mammary Carcinoma / V. d. Giorgi;R. Santi;M. Grazzini;F. Papi;A. Gori;S. Rossari;D. Massi;T. Lotti. - In: ACTA DERMATO-VENEREOLOGICA. - ISSN 0001-5555. - ELETTRONICO. - 90:(2010), pp. 283-286. [10.2340/00015555-0841]
Titolo: | Synchronous Angiosarcoma, Melanoma and Morphea of the Breast Skin 14 years After Radiotherapy for Mammary Carcinoma | |
Autori di Ateneo: | ||
Autori: | V. d. Giorgi; R. Santi; M. Grazzini; F. Papi; GORI, ALESSIA; S. Rossari; MASSI, DANIELA; LOTTI, TORELLO | |
Data di pubblicazione: | 2010 | |
Rivista: | ||
Volume: | 90 | |
Pagina iniziale: | 283 | |
Pagina finale: | 286 | |
Abstract: | With the improvement in survival after breast cancer there has been increasing interest in the long-term effects of radiotherapy, including the development of tumours. Compared with the general population, breast cancer survivors have a 10-50% higher risk of developing a second cancer. Radiotherapy may play a role in the onset of such lesions. We describe here the case of a 68-year-old woman who developed synchronous cutaneous angiosarcoma, melanoma and morphea of the breast skin and the local area, 14 years after radiotherapy for breast carcinoma. Given the risk of post-radiation secondary primaries in breast cancer patients, long-term surveillance is necessary, with particular attention being paid to skin changes in the irradiation field. Radiation-induced morphea is a rare complication in which immunological abnormalities may stimulate malignant transformation. Long-term studies are required to clarify the pathogenesis of these rare associations. | |
Handle: | http://hdl.handle.net/2158/394342 | |
Appare nelle tipologie: | 1a - Articolo su rivista |