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EnglishAn invariable feature of Helicobacter pylori-infected gastric mucosa is the persistent infiltration of inflammatory cells. The neutrophil-activating protein (HP-NAP) has a pivotal role in triggering and orchestrating the phlogistic process associated with H. pylori infection. Aim of this study was to address whether HP-NAP might further contribute to the inflammation by increasing the lifespan of inflammatory cells. We report that HP-NAP is able to prolong the lifespan of monocytes, in parallel with the induction of the anti-apoptotic proteins A1, Mcl-1, Bcl-2 and Bcl-X(L). This effect does not result from a direct action on the apoptotic machinery, but rather it requires the release of endogenous pro-survival factors, such as interleukin-1beta, which probably acts in synergy with other unidentified mediators. We also report that HP-NAP promotes the survival of Ficoll-purified neutrophils in a monocyte-dependent fashion: indeed, mononuclear cell depletion of Ficoll-purified neutrophils completely abolished the pro-survival effect by HP-NAP. In conclusion, our data reinforce the notion that HP-NAP has a pivotal role in sustaining a prolonged activation of myeloid cells.
Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils / Cappon, A.; Babolin, C.; Segat D, D.; Cancian, L.; Amedei, Amedeo; Calzetti, F.; Cassatella, M. A.; D'Elios, MARIO MILCO; de Bernard, M.. - In: CELLULAR MICROBIOLOGY. - ISSN 1462-5814. - STAMPA. - 12(2010), pp. 754-764. [10.1111/j.1462-5822.2010.01431.x]
| Titolo: | Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils. | |
| Autori di Ateneo: | ||
| Autori: | A. Cappon; C. Babolin; D. Segat D; L. Cancian; AMEDEI, AMEDEO; F. Calzetti; M.A. Cassatella; D'ELIOS, MARIO MILCO; M. de Bernard | |
| Anno di registrazione: | 2010 | |
| Rivista: | ||
| Volume: | 12 | |
| Pagina iniziale: | 754 | |
| Pagina finale: | 764 | |
| Abstract: | An invariable feature of Helicobacter pylori-infected gastric mucosa is the persistent infiltration of inflammatory cells. The neutrophil-activating protein (HP-NAP) has a pivotal role in triggering and orchestrating the phlogistic process associated with H. pylori infection. Aim of this study was to address whether HP-NAP might further contribute to the inflammation by increasing the lifespan of inflammatory cells. We report that HP-NAP is able to prolong the lifespan of monocytes, in parallel with the induction of the anti-apoptotic proteins A1, Mcl-1, Bcl-2 and Bcl-X(L). This effect does not result from a direct action on the apoptotic machinery, but rather it requires the release of endogenous pro-survival factors, such as interleukin-1beta, which probably acts in synergy with other unidentified mediators. We also report that HP-NAP promotes the survival of Ficoll-purified neutrophils in a monocyte-dependent fashion: indeed, mononuclear cell depletion of Ficoll-purified neutrophils completely abolished the pro-survival effect by HP-NAP. In conclusion, our data reinforce the notion that HP-NAP has a pivotal role in sustaining a prolonged activation of myeloid cells. | |
| Handle: | http://hdl.handle.net/2158/394964 | |
| Appare nelle tipologie: | 1a - Articolo su rivista |
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http://hdl.handle.net/2158/394964
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