FLORE (FLOrence REsearch) è il repository istituzionale ad accesso pieno e aperto dell'Università degli Studi di Firenze.
Raccoglie, documenta e conserva le informazioni sulla produzione scientifica dell'Università e costituisce l'Anagrafe della ricerca dell'Ateneo.
EnglishThe conceptus is considered a semi-allograft because of the presence of paternal HLA-C molecules. These alloantigens can be processed by maternal antigen presenting cells, which present them to specific maternal CD4+ T cells. After activation, the maternal CD4+ T cells can become effector decidual CD4+ T cells, which are able to release various cytokines. Th1-type cytokines (IFNgamma) that promote allograft rejection may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-10) that inhibit Th1 responses, promote allograft tolerance and therefore may improve fetal survival. A collaborative interaction between the decidual natural regulatory T cells, CD4+ CD25+ Foxp3 T cells and NKT cells in preventing fetal allograft rejection is suggested.
T cell tolerance towards the fetal allograft / M.P. Piccinni. - In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY. - ISSN 0165-0378. - STAMPA. - 85(2010), pp. 71-75.
| Titolo: | T cell tolerance towards the fetal allograft | |
| Autori di Ateneo: | ||
| Autori: | PICCINNI, MARIE-PIERRE | |
| Data di pubblicazione: | 2010 | |
| Rivista: | ||
| Volume: | 85 | |
| Pagina iniziale: | 71 | |
| Pagina finale: | 75 | |
| Abstract: | The conceptus is considered a semi-allograft because of the presence of paternal HLA-C molecules. These alloantigens can be processed by maternal antigen presenting cells, which present them to specific maternal CD4+ T cells. After activation, the maternal CD4+ T cells can become effector decidual CD4+ T cells, which are able to release various cytokines. Th1-type cytokines (IFNgamma) that promote allograft rejection may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-10) that inhibit Th1 responses, promote allograft tolerance and therefore may improve fetal survival. A collaborative interaction between the decidual natural regulatory T cells, CD4+ CD25+ Foxp3 T cells and NKT cells in preventing fetal allograft rejection is suggested. | |
| Handle: | http://hdl.handle.net/2158/395111 | |
| Appare nelle tipologie: | 1a - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 1-s2.0-S0165037810000410-main T cell tolerance.pdf | Pdf editoriale (Version of record) | DRM non definito | Administrator Richiedi una copia |
http://hdl.handle.net/2158/395111
Copyright © 2022