Negative Influence of HIV Infection on Day-Night Blood Pressure Variability.

De Socio, G. V. L.; Bonfanti, P.; Martinelli, C.; Ricci, E.; Pucci, G.; Marinoni, Marinella; Vitiello, P.; Menzaghi, B.; Rizzardini, G.; Schillaci, G.

doi:10.1097/QAI.0b013e3181e46456

OBJECTIVE:: An attenuation of the physiological day-night blood pressure (BP) reduction is an important predictor of cardiovascular (CV) events and death. We compared circadian BP profile in treatment-naive HIV-infected patients and in healthy control subjects. METHODS:: Fifty-two antiretroviral therapy-naive HIV-infected patients (85\% men, age 39 ± 11 years, BP 125/78 ± 11/9 mm Hg) and 156 age- and BP-matched HIV-negative controls (85\% men, age 39 ± 10 years, BP 125/78 ± 9/7 mm Hg) underwent 24-hour BP monitoring. Subjects with a nocturnal reduction of systolic BP <10\% were defined as "nondippers." RESULTS:: Nighttime BP was higher in HIV-infected subjects (113/69 ± 11/9 vs 109/67 ± 8/6 mm Hg, P = 0.008/0.005). Nocturnal systolic/diastolic BP reduction was 8.8/13.2\% in HIV-positive patients and 11.7/17.2\% in HIV negative (P = 0.002/0.001). The prevalence of "nondippers" was 35\% and 15\%, respectively (P = 0.003). In multivariate analysis, nocturnal systolic BP fall was negatively associated to HIV infection (β = -0.22, P = 0.001). HIV viral load, low CD4 cell count, and AIDS progression risk were all related with a flattened day-night BP profile (P < 0.01). CONCLUSIONS:: HIV infection per se negatively affects circadian BP rhythm. These findings, obtained in subjects without major CV risk factors and antiretroviral naive, suggest that day-night BP changes may play a role in the HIV-related increase in CV risk.

Negative Influence of HIV Infection on Day-Night Blood Pressure Variability / G. V. L De Socio;P. Bonfanti;C. Martinelli;E. Ricci;G. Pucci;M. Marinoni;P. Vitiello;B. Menzaghi;G. Rizzardini;G. Schillaci. - In: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - ISSN 1525-4135. - STAMPA. - 55(2010), pp. 356-360. [10.1097/QAI.0b013e3181e46456]

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Titolo:	Negative Influence of HIV Infection on Day-Night Blood Pressure Variability.
Autori di Ateneo:	G. V. L. De Socio P. Bonfanti C. Martinelli E. Ricci G. Pucci MARINONI, MARINELLA P. Vitiello B. Menzaghi G. Rizzardini G. Schillaci mostra contributor esterni nascondi contributor esterni
Autori:	G. V. L. De Socio; P. Bonfanti; C. Martinelli; E. Ricci; G. Pucci; MARINONI, MARINELLA; P. Vitiello; B. Menzaghi; G. Rizzardini; G. Schillaci
Data di pubblicazione:	2010
Rivista:	JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume:	55
Pagina iniziale:	356
Pagina finale:	360
Abstract:	OBJECTIVE:: An attenuation of the physiological day-night blood pressure (BP) reduction is an important predictor of cardiovascular (CV) events and death. We compared circadian BP profile in treatment-naive HIV-infected patients and in healthy control subjects. METHODS:: Fifty-two antiretroviral therapy-naive HIV-infected patients (85\% men, age 39 ± 11 years, BP 125/78 ± 11/9 mm Hg) and 156 age- and BP-matched HIV-negative controls (85\% men, age 39 ± 10 years, BP 125/78 ± 9/7 mm Hg) underwent 24-hour BP monitoring. Subjects with a nocturnal reduction of systolic BP <10\% were defined as "nondippers." RESULTS:: Nighttime BP was higher in HIV-infected subjects (113/69 ± 11/9 vs 109/67 ± 8/6 mm Hg, P = 0.008/0.005). Nocturnal systolic/diastolic BP reduction was 8.8/13.2\% in HIV-positive patients and 11.7/17.2\% in HIV negative (P = 0.002/0.001). The prevalence of "nondippers" was 35\% and 15\%, respectively (P = 0.003). In multivariate analysis, nocturnal systolic BP fall was negatively associated to HIV infection (β = -0.22, P = 0.001). HIV viral load, low CD4 cell count, and AIDS progression risk were all related with a flattened day-night BP profile (P < 0.01). CONCLUSIONS:: HIV infection per se negatively affects circadian BP rhythm. These findings, obtained in subjects without major CV risk factors and antiretroviral naive, suggest that day-night BP changes may play a role in the HIV-related increase in CV risk.
Handle:	http://hdl.handle.net/2158/395277
Appare nelle tipologie:	1a - Articolo su rivista

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