OBJECTIVE:: An attenuation of the physiological day-night blood pressure (BP) reduction is an important predictor of cardiovascular (CV) events and death. We compared circadian BP profile in treatment-naive HIV-infected patients and in healthy control subjects. METHODS:: Fifty-two antiretroviral therapy-naive HIV-infected patients (85\% men, age 39 ± 11 years, BP 125/78 ± 11/9 mm Hg) and 156 age- and BP-matched HIV-negative controls (85\% men, age 39 ± 10 years, BP 125/78 ± 9/7 mm Hg) underwent 24-hour BP monitoring. Subjects with a nocturnal reduction of systolic BP <10\% were defined as "nondippers." RESULTS:: Nighttime BP was higher in HIV-infected subjects (113/69 ± 11/9 vs 109/67 ± 8/6 mm Hg, P = 0.008/0.005). Nocturnal systolic/diastolic BP reduction was 8.8/13.2\% in HIV-positive patients and 11.7/17.2\% in HIV negative (P = 0.002/0.001). The prevalence of "nondippers" was 35\% and 15\%, respectively (P = 0.003). In multivariate analysis, nocturnal systolic BP fall was negatively associated to HIV infection (β = -0.22, P = 0.001). HIV viral load, low CD4 cell count, and AIDS progression risk were all related with a flattened day-night BP profile (P < 0.01). CONCLUSIONS:: HIV infection per se negatively affects circadian BP rhythm. These findings, obtained in subjects without major CV risk factors and antiretroviral naive, suggest that day-night BP changes may play a role in the HIV-related increase in CV risk.
Negative Influence of HIV Infection on Day-Night Blood Pressure Variability / G. V. L De Socio;P. Bonfanti;C. Martinelli;E. Ricci;G. Pucci;M. Marinoni;P. Vitiello;B. Menzaghi;G. Rizzardini;G. Schillaci. - In: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - ISSN 1525-4135. - STAMPA. - 55(2010), pp. 356-360. [10.1097/QAI.0b013e3181e46456]
Titolo: | Negative Influence of HIV Infection on Day-Night Blood Pressure Variability. | |
Autori di Ateneo: | ||
Autori: | G. V. L. De Socio; P. Bonfanti; C. Martinelli; E. Ricci; G. Pucci; MARINONI, MARINELLA; P. Vitiello; B. Menzaghi; G. Rizzardini; G. Schillaci | |
Data di pubblicazione: | 2010 | |
Rivista: | ||
Volume: | 55 | |
Pagina iniziale: | 356 | |
Pagina finale: | 360 | |
Abstract: | OBJECTIVE:: An attenuation of the physiological day-night blood pressure (BP) reduction is an important predictor of cardiovascular (CV) events and death. We compared circadian BP profile in treatment-naive HIV-infected patients and in healthy control subjects. METHODS:: Fifty-two antiretroviral therapy-naive HIV-infected patients (85\% men, age 39 ± 11 years, BP 125/78 ± 11/9 mm Hg) and 156 age- and BP-matched HIV-negative controls (85\% men, age 39 ± 10 years, BP 125/78 ± 9/7 mm Hg) underwent 24-hour BP monitoring. Subjects with a nocturnal reduction of systolic BP <10\% were defined as "nondippers." RESULTS:: Nighttime BP was higher in HIV-infected subjects (113/69 ± 11/9 vs 109/67 ± 8/6 mm Hg, P = 0.008/0.005). Nocturnal systolic/diastolic BP reduction was 8.8/13.2\% in HIV-positive patients and 11.7/17.2\% in HIV negative (P = 0.002/0.001). The prevalence of "nondippers" was 35\% and 15\%, respectively (P = 0.003). In multivariate analysis, nocturnal systolic BP fall was negatively associated to HIV infection (β = -0.22, P = 0.001). HIV viral load, low CD4 cell count, and AIDS progression risk were all related with a flattened day-night BP profile (P < 0.01). CONCLUSIONS:: HIV infection per se negatively affects circadian BP rhythm. These findings, obtained in subjects without major CV risk factors and antiretroviral naive, suggest that day-night BP changes may play a role in the HIV-related increase in CV risk. | |
Handle: | http://hdl.handle.net/2158/395277 | |
Appare nelle tipologie: | 1a - Articolo su rivista |
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