Various studies have evaluated the possible role of the -1438 G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438 G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P=0.003 and P=0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P=0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies
Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa / Ricca V; Nacmias B; Boldrini M; Cellini E; di Bernardo M; Ravaldi C; Tedde A; Bagnoli S; Placidi GF; Rotella CM; Sorbi S.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - ELETTRONICO. - 365:(2004), pp. 92-96.
Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa.
RICCA, VALDO;NACMIAS, BENEDETTA;CELLINI, ELENA;Ravaldi C;TEDDE, ANDREA;BAGNOLI, SILVIA;ROTELLA, CARLO MARIA;SORBI, SANDRO
2004
Abstract
Various studies have evaluated the possible role of the -1438 G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438 G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P=0.003 and P=0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P=0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studiesI documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.