Sinonasal intestinal type adenocarcinoma (ITAC) is a rare subtype of adenocarcinoma strongly associated with professional exposure to wood or leather dusts. It is an aggressive tumor, with an estimated 5-year survival of 40\%. Herein, we report a series of 55 cases tested for epidermal growth factor receptor protein expression and epidermal growth factor receptor gene copy gains, through immunohistochemistry and fluorescence in situ hybridization. Eighteen tumors (32.7\%) showed EGFR positivity, seven of which exhibited high expression levels of the receptor. The frequency of EGF-R overexpression was significantly higher in tumors from woodworkers (6 of 14, 42.8\%) than in tumors from leatherworkers (2 of 21, 9.5\%), or arising in subjects with no known occupational history (0 of 8) (P=0.015, Pearson chi square). No correlation was found with other clinico-pathological parameters, including histologic subtype, stage, overall, and disease free survival. In cases with EGFR overexpression, fluorescent in situ hybridization analysis revealed disomy in three adenocarcinomas, chromosome 7 polysomy in two, and EGFR gene amplification in three. In conclusion, a subset of ITAC, mostly occurring in woodworkers, express high levels of EGFR and this is often associated with either gene amplification or chromosome 7 polysomy. EGFR targeted therapies could therefore be investigated prospectively in this group of tumors.

Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma / A. Franchi;C. Fondi;M. Paglierani;M. Pepi;O. Gallo;M. Santucci. - In: ORAL ONCOLOGY. - ISSN 1368-8375. - STAMPA. - 45:(2009), pp. 835-838. [10.1016/j.oraloncology.2008.12.005]

Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma.

FRANCHI, ALESSANDRO;FONDI, CRISTINA;GALLO, ORESTE;SANTUCCI, MARCO
2009

Abstract

Sinonasal intestinal type adenocarcinoma (ITAC) is a rare subtype of adenocarcinoma strongly associated with professional exposure to wood or leather dusts. It is an aggressive tumor, with an estimated 5-year survival of 40\%. Herein, we report a series of 55 cases tested for epidermal growth factor receptor protein expression and epidermal growth factor receptor gene copy gains, through immunohistochemistry and fluorescence in situ hybridization. Eighteen tumors (32.7\%) showed EGFR positivity, seven of which exhibited high expression levels of the receptor. The frequency of EGF-R overexpression was significantly higher in tumors from woodworkers (6 of 14, 42.8\%) than in tumors from leatherworkers (2 of 21, 9.5\%), or arising in subjects with no known occupational history (0 of 8) (P=0.015, Pearson chi square). No correlation was found with other clinico-pathological parameters, including histologic subtype, stage, overall, and disease free survival. In cases with EGFR overexpression, fluorescent in situ hybridization analysis revealed disomy in three adenocarcinomas, chromosome 7 polysomy in two, and EGFR gene amplification in three. In conclusion, a subset of ITAC, mostly occurring in woodworkers, express high levels of EGFR and this is often associated with either gene amplification or chromosome 7 polysomy. EGFR targeted therapies could therefore be investigated prospectively in this group of tumors.
2009
45
835
838
A. Franchi;C. Fondi;M. Paglierani;M. Pepi;O. Gallo;M. Santucci
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/398400
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