We demonstrate the feasibility of time-resolved diffuse reflectance measurements at small sourcedetector separations using a single-photon avalanche diode operated in time-gated mode. Photon time distributions at an interfiber distance of 2 mm were obtained on a homogeneous tissue phantom with a dynamic range of 106 and collecting photons at arrival times up to 4 ns. Moreover, we were able to detect a local inhomogeneity deeply buried within a diffusive medium with better spatial resolution, higher signal intensity, and same contrast of a larger (20 mm) interfiber distance. Finally, the proposed approach proved valuable to detect in vivo a task-related brain activation.
Time-Resolved Diffuse Reflectance Using Small Source-Detector Separation and Fast Single-Photon Gating / A. Pifferi; A. Torricelli; L. Spinelli; D. Contini; R. Cubeddu; F. Martelli; G. Zaccanti; A. Tosi; A. Dalla Mora; F. Zappa; S. Cova. - In: PHYSICAL REVIEW LETTERS. - ISSN 0031-9007. - STAMPA. - 100:(2008), pp. 138101(1)-138101(4). [10.1103/PhysRevLett.100.138101]
Time-Resolved Diffuse Reflectance Using Small Source-Detector Separation and Fast Single-Photon Gating
MARTELLI, FABRIZIO;ZACCANTI, GIOVANNI;
2008
Abstract
We demonstrate the feasibility of time-resolved diffuse reflectance measurements at small sourcedetector separations using a single-photon avalanche diode operated in time-gated mode. Photon time distributions at an interfiber distance of 2 mm were obtained on a homogeneous tissue phantom with a dynamic range of 106 and collecting photons at arrival times up to 4 ns. Moreover, we were able to detect a local inhomogeneity deeply buried within a diffusive medium with better spatial resolution, higher signal intensity, and same contrast of a larger (20 mm) interfiber distance. Finally, the proposed approach proved valuable to detect in vivo a task-related brain activation.File | Dimensione | Formato | |
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