We characterize the capability of time-resolved reflectance measurements at small source-detector separation less than 5 mm to localize small inhomogeneities embedded in an otherwise homogeneous or layered diffusive medium. By considering both absorption and scattering inhomogeneities, we demonstrate the improvement of this approach in terms of contrast and spatial resolution, as compared to more typical set-ups involving larger source-detection separations few centimeters. Simulations are performed exploiting an analytical perturbation approach to diffusion theory and a four-layer heterogeneous time-resolved Monte Carlo code, considering realistic tissue geometries.

Absorption and scattering perturbations in homogeneous and layered diffusive media probed by time-resolved reflectance at null source-detector separation / L. Spinelli; F. Martelli; S. Del Bianco; A. Pifferi; A. Torricelli; R. Cubeddu; G. Zaccanti. - In: PHYSICAL REVIEW E, STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS. - ISSN 1539-3755. - STAMPA. - 74:(2006), pp. 021919-1-021919-8. [10.1103/PhysRevE.74.021919]

Absorption and scattering perturbations in homogeneous and layered diffusive media probed by time-resolved reflectance at null source-detector separation

MARTELLI, FABRIZIO
Supervision
;
ZACCANTI, GIOVANNI
2006

Abstract

We characterize the capability of time-resolved reflectance measurements at small source-detector separation less than 5 mm to localize small inhomogeneities embedded in an otherwise homogeneous or layered diffusive medium. By considering both absorption and scattering inhomogeneities, we demonstrate the improvement of this approach in terms of contrast and spatial resolution, as compared to more typical set-ups involving larger source-detection separations few centimeters. Simulations are performed exploiting an analytical perturbation approach to diffusion theory and a four-layer heterogeneous time-resolved Monte Carlo code, considering realistic tissue geometries.
2006
74
021919-1
021919-8
Goal 3: Good health and well-being
L. Spinelli; F. Martelli; S. Del Bianco; A. Pifferi; A. Torricelli; R. Cubeddu; G. Zaccanti
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/400046
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