Abstract: A variety of conflicting results appeared in the literature concerning the effect of dominant oncogenes on the sensitivity to irradiation and to anticancer agents in a number of cell lines of human and animal origin. In this report we provide evidence supporting the hypothesis that the tumor suppressor gene p53 and the apoptosis suppressor gene bcl2 modulate the effect of dominant oncogenes and that the effect of dominant oncogenes on resistance or sensitivity is dependent on the balance between the expression of p53 and bcl2.
Dominant oncogenes, tumor suppressors and radiosensitivity / V. CHIARUGI; L. MAGNELLI; M. CINELLI; A. TURCHETTI; M. RUGGIERO. - In: CELLULAR & MOLECULAR BIOLOGY RESEARCH. - ISSN 0968-8773. - STAMPA. - 41:(1995), pp. 161-166.
Dominant oncogenes, tumor suppressors and radiosensitivity
CHIARUGI, VINCENZO;MAGNELLI, LUCIA;RUGGIERO, MARCO
1995
Abstract
Abstract: A variety of conflicting results appeared in the literature concerning the effect of dominant oncogenes on the sensitivity to irradiation and to anticancer agents in a number of cell lines of human and animal origin. In this report we provide evidence supporting the hypothesis that the tumor suppressor gene p53 and the apoptosis suppressor gene bcl2 modulate the effect of dominant oncogenes and that the effect of dominant oncogenes on resistance or sensitivity is dependent on the balance between the expression of p53 and bcl2.
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
