The first crystal structures of Berberine and Sanguinarine intercalated with d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form
X-ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine in complex with double helix DNA d(CGTACG) / M.Ferraroni; C. Bazzicalupi; A.R. Bilia; P. Gratteri. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 47:(2011), pp. 4917-4919. [10.1039/C1CC10971E]
X-ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine in complex with double helix DNA d(CGTACG)
FERRARONI, MARTA;BAZZICALUPI, CARLA;BILIA, ANNA RITA;GRATTERI, PAOLA
2011
Abstract
The first crystal structures of Berberine and Sanguinarine intercalated with d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium formFile | Dimensione | Formato | |
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