miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity.

Experience-dependent expression of miR-132 regulates ocular dominance plasticity / P.Tognini; E.Putignano; A.Coatti; T.Pizzorusso. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - STAMPA. - 14:(2011), pp. 1237-1239. [10.1038/nn.2920]

Experience-dependent expression of miR-132 regulates ocular dominance plasticity

PIZZORUSSO, TOMMASO
2011

Abstract

miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity.
2011
14
1237
1239
P.Tognini; E.Putignano; A.Coatti; T.Pizzorusso
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/520272
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