Poly(ADP-Ribose) polymerase (PARP) activity has been demonstrated fundamental in many cellular processes, including DNA repair, cell proliferation and differentiation. In particular, PARP activity has been recently found to affect proliferation, migration, and tube formation of human umbilical vein endothelial cells. In recent times, PARP inhibitors have entered in clinical trials to potentiate cancer treatments by preventing DNA repair, but little is known about the effects performed by different drug concentrations on neoangiogenesis, an essential step in tumor growth.

Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2 / R.Caldini; E.Fanti; L.Magnelli; E.Barletta; E.Tanganelli; M.Zampieri; M.Chevanne. - In: VASCULAR CELL. - ISSN 2045-824X. - ELETTRONICO. - 3:12:(2011), pp. 0-0. [10.1186/2045-824X-3-12]

Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2

CALDINI, RICCARDO;MAGNELLI, LUCIA;BARLETTA, EMANUELA;TANGANELLI, ELISABETTA;CHEVANNE, MARTA
2011

Abstract

Poly(ADP-Ribose) polymerase (PARP) activity has been demonstrated fundamental in many cellular processes, including DNA repair, cell proliferation and differentiation. In particular, PARP activity has been recently found to affect proliferation, migration, and tube formation of human umbilical vein endothelial cells. In recent times, PARP inhibitors have entered in clinical trials to potentiate cancer treatments by preventing DNA repair, but little is known about the effects performed by different drug concentrations on neoangiogenesis, an essential step in tumor growth.
2011
3:12
0
0
R.Caldini; E.Fanti; L.Magnelli; E.Barletta; E.Tanganelli; M.Zampieri; M.Chevanne
File in questo prodotto:
File Dimensione Formato  
art%3A10.1186%2F2045-824X-3-12.pdf

accesso aperto

Descrizione: Articolo principale
Tipologia: Pdf editoriale (Version of record)
Licenza: Open Access
Dimensione 1.27 MB
Formato Adobe PDF
1.27 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/534057
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 18
  • ???jsp.display-item.citation.isi??? ND
social impact