Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/ translation are somehow frozen due to meiosis block or DNA condensationrespectively. A kinaseanchoring proteins (AKAPs) represent a functional conserved family of signal-organizing scaffolding proteins, which due to the specific subcellular distribution and focally compartmentalized cyclic-AMP-dependent protein kinase (PKA) and other enzymes, assuring the coordination of cAMP-responsive events and their integration with other intracellular signals. This review summarizes the actual knowledge on AKAP structure and functions, taking into particular account the role of different AKAPs in regulating reproductive functions such as gametogenesis. Evidence for sperm specific AKAP isoforms and their initiated signaling cascades in mature sperm and the role of this focally activated super-molecular signaling complex in motility are discussed in details with particular emphasis on putative relations between AKAP structural and functional alterations and defects in sperm motility.

Role of a-kinase anchoring proteins (AKAPs) in reproduction / M. Luconi; G. Cantini; E. Baldi; G. Forti. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-9946. - STAMPA. - 16:(2011), pp. 1315-1330. [10.2741/3791]

Role of a-kinase anchoring proteins (AKAPs) in reproduction

LUCONI, MICHAELA;CANTINI, GIULIA;BALDI, ELISABETTA;FORTI, GIANNI
2011

Abstract

Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/ translation are somehow frozen due to meiosis block or DNA condensationrespectively. A kinaseanchoring proteins (AKAPs) represent a functional conserved family of signal-organizing scaffolding proteins, which due to the specific subcellular distribution and focally compartmentalized cyclic-AMP-dependent protein kinase (PKA) and other enzymes, assuring the coordination of cAMP-responsive events and their integration with other intracellular signals. This review summarizes the actual knowledge on AKAP structure and functions, taking into particular account the role of different AKAPs in regulating reproductive functions such as gametogenesis. Evidence for sperm specific AKAP isoforms and their initiated signaling cascades in mature sperm and the role of this focally activated super-molecular signaling complex in motility are discussed in details with particular emphasis on putative relations between AKAP structural and functional alterations and defects in sperm motility.
2011
16
1315
1330
M. Luconi; G. Cantini; E. Baldi; G. Forti
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/537260
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