Erythropoietin is a glycoproteic hormone of 165 aminoacids belonging to hemopoietic growth factors. Recombinant EPO has been introduced in early '80 to treat patients with severe anemia and to reduce side effects other EPO produced in eukaryotes have been introduced and different analogs produced over years. Since 2004, when EPO alfa and beta patents were over other molecules have appeared as EPO derivatives. EPO results in the prohibited list of World Anti-doping organization (WADA) and their abuse should be controlled in sport. EPO analysis is quite difficult since the molecule has relatively short half-life, numerous isoforms and many analogs are present on the market. We will report about EPO detection in urine samples. To achieve this, antibodies were used as recognition elements in sensing developments using Surface Plasmon Resonance (SPR) as transduction principle. © 2012 Springer Science+Business Media, LLC.
Erythropoietin Detection: A Biosensor Approach / S. Scarano; M.L. Ermini; S. Tombelli; M. Mascini; M. Minunni;. - ELETTRONICO. - 109:(2012), pp. 9-13. (Intervento presentato al convegno Italian association of Sensors and Microsystems (AISEM) tenutosi a Roma, Italy nel 7-9 February 2011) [10.1007/978-1-4614-0935-9_2].
Erythropoietin Detection: A Biosensor Approach
SCARANO, SIMONA;ERMINI, MARIA LAURA;MINUNNI, MARIA
2012
Abstract
Erythropoietin is a glycoproteic hormone of 165 aminoacids belonging to hemopoietic growth factors. Recombinant EPO has been introduced in early '80 to treat patients with severe anemia and to reduce side effects other EPO produced in eukaryotes have been introduced and different analogs produced over years. Since 2004, when EPO alfa and beta patents were over other molecules have appeared as EPO derivatives. EPO results in the prohibited list of World Anti-doping organization (WADA) and their abuse should be controlled in sport. EPO analysis is quite difficult since the molecule has relatively short half-life, numerous isoforms and many analogs are present on the market. We will report about EPO detection in urine samples. To achieve this, antibodies were used as recognition elements in sensing developments using Surface Plasmon Resonance (SPR) as transduction principle. © 2012 Springer Science+Business Media, LLC.
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