The mechanisms responsible for mesangial cell proliferation in proliferative glomerulonephritis are only partially understood. This article reports the results of an immunohistochemical study showing high expression of the chemokine receptor CXCR3 by mesangial cells of patients with IgA nephropathy, membranoproliferative glomerulonephritis, or rapidly progressive glomerulonephritis. CXCR3 was also detectable by flow cytometry in cultured human mesangial cells, in which it appeared to be functionally active, as determined by the ability of its ligand, the (interferon-gamma)-inducible protein of 10 kD (IP-10) to induce intracellular Ca2+ influx. Both IP-10 and the monokine induced by interferon-gamma (Mig) were also effective in inducing proliferation of human mesangial cells. These data suggest that in patients with proliferative glomerulonephritis, the chemokines IP-10 and/or Mig not only may act as chemoattractants for infiltrating mononuclear cells in the inflamed tissue, but also may directly induce the proliferation of mesangial cells.

Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis / P.Romagnani; C.Beltrame; F.Annunziato; L.Lasagni; M.Luconi; G.Galli; L.Cosmi; E.Maggi; M.Salvadori; C.Pupilli; M.Serio. - In: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. - ISSN 1046-6673. - STAMPA. - 10:(1999), pp. 2518-2526.

Role for interactions between IP-10/Mig and CXCR3 in proliferative glomerulonephritis

ROMAGNANI, PAOLA;ANNUNZIATO, FRANCESCO;LASAGNI, LAURA;LUCONI, MICHAELA;COSMI, LORENZO;MAGGI, ENRICO;PUPILLI, CINZIA;SERIO, MARIO
1999

Abstract

The mechanisms responsible for mesangial cell proliferation in proliferative glomerulonephritis are only partially understood. This article reports the results of an immunohistochemical study showing high expression of the chemokine receptor CXCR3 by mesangial cells of patients with IgA nephropathy, membranoproliferative glomerulonephritis, or rapidly progressive glomerulonephritis. CXCR3 was also detectable by flow cytometry in cultured human mesangial cells, in which it appeared to be functionally active, as determined by the ability of its ligand, the (interferon-gamma)-inducible protein of 10 kD (IP-10) to induce intracellular Ca2+ influx. Both IP-10 and the monokine induced by interferon-gamma (Mig) were also effective in inducing proliferation of human mesangial cells. These data suggest that in patients with proliferative glomerulonephritis, the chemokines IP-10 and/or Mig not only may act as chemoattractants for infiltrating mononuclear cells in the inflamed tissue, but also may directly induce the proliferation of mesangial cells.
1999
10
2518
2526
P.Romagnani; C.Beltrame; F.Annunziato; L.Lasagni; M.Luconi; G.Galli; L.Cosmi; E.Maggi; M.Salvadori; C.Pupilli; M.Serio
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/543289
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