Stereoselective synthesis of Beta3-Amino Acids and Beta-Oligopeptides promoted by Organoselenium Intermediates

Propargylic amines can be valid precursors for the synthesis of β3-amino acids. This can be effected by a selenium-mediated conversion of the carbon-carbon triple bond to a, Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols, or the amine of an amino acid derivative to give β3-amino acids, β3-amino esters, or mixed peptides, respectively