The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed "click-chemistry", and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.
1,2,3-triazole-based peptidomimetic integrin inhibitors for the diagnosis and therapy of tumors / A.Guarna; G.Menchi; N.Cini; A.Trabocchi; A.Pupi; A.Bottoncetti; S.Raspanti; L.Calorini. - (2010).
1,2,3-triazole-based peptidomimetic integrin inhibitors for the diagnosis and therapy of tumors
GUARNA, ANTONIO;MENCHI, GLORIA;CINI, NICOLETTA;TRABOCCHI, ANDREA;PUPI, ALBERTO;BOTTONCETTI, ANNA;RASPANTI, SILVIA;CALORINI, LIDO
2010
Abstract
The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed "click-chemistry", and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.
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