Beating heart myocardial revascularization on extracorporeal circulation in patients with end-stage coronary artery disease

To evaluate in a cohort of ESCAD patients (pts) the effects of on-pump/beating-heart versus conventional CABG in terms of early and mid-term survival and morbidity and LV function improvement. Methods: Between January 1993 and December 2000, 78 (Group I) ESCAD pts underwent on-pump/beating-heart surgery. Mean age in Group I was 66.2±6 (58-79), NYHA and CCS class were 3.2±0.6 and 3.3±0.4 respectively, Myocardial viability index 0.69±0.1 (%), LVEF (%) 24.8±4, LVEDP (mmHg) 28.1±5.8 and LVEDD(mm) 69.5±6. Group II consisted in 78 ESCAD patients undergoing conventional CABG selected in a randomized fashion from an age, sex, and LVEF corrected group of patients. Mean age in Group II was 65.7±5 (57-78), NYHA 3.1±0.7, CCS 3.4±0.8, LVEF(%) 25±5, LVEDP(mmHg) 27.9±4.4 and LVEDD(mm) 69.2±7.2. Results: Postoperatively, 5(7.7%) patients died in Group I versus 7(11.5%) patients in Group II (P>0.1). CPB time resulted to be in Group II patients (P=0.001) and the mean distal anastomoses per patient was similar between groups (P=Ns). Perioperative AMI (P=0.039), LCOS (P=0.002), necessity for ultrafiltration (P=0.018) and bleeding>1000 ml (P=0.029) were significantly higher in Group II. None of the Group I patients underwent surgical revision for bleeding versus 8(10.3%) patients in Group II (P=0.011). At 6 months after surgery, the LV function improved significantly in Group I patients, demonstrated by an increased LVEF=27.2±4(%)(P=0.001), lower LVEDP=26.4±3(mmHg)(P=0.029) and LVEDD=67±4(mm) (P=0.004) instead of a lower LVEDD=66.8±6(mm)(P=0.032) versus the preoperative data in Group II. The actuarial survival at 1, 3 and 5 yr were 90, 82 and 71% in Group I and 89, 83 and 74% in Group II (P=Ns). Conclusion: In ESCAD patients who may poorly tolerate cardioplegic arrest, on-pump/beating-heart CABG may be an acceptable alternative associated with lower postoperative mortality and morbidity. Such a technique offers a better myocardial and renal protection associated with lower postoperative complications due to intraoperative hypoperfusion.