Oleuropein aglycone is able to interfere with the aggregation path of Abeta(1-42) skipping the formation of toxic oligomers. It also affects preformed fibril deposits, by reducing their density without determining the release of toxic fragments.
Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon / S.Rigacci; V.Guidotti; M.Bucciantini; D.Nichino; A.Relini; A.Berti; M.Stefani. - In: CURRENT ALZHEIMER RESEARCH. - ISSN 1567-2050. - STAMPA. - 8:(2011), pp. 841-852.
Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon
RIGACCI, STEFANIA;BUCCIANTINI, MONICA;BERTI, ANDREA;STEFANI, MASSIMO
2011
Abstract
Oleuropein aglycone is able to interfere with the aggregation path of Abeta(1-42) skipping the formation of toxic oligomers. It also affects preformed fibril deposits, by reducing their density without determining the release of toxic fragments.
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