Alzheimer's disease (AD) is the most common form of dementia clinically characterized by progressive impairment of memory and other cognitive functions. Many genetic researches in AD identified one common genetic variant (ε4) in Apolipoprotein E (APOE) gene as a risk factor for the disease. Two independent genome-wide studies demonstrated a new locus on chromosome 9p21.3 implicated in Late-Onset Alzheimer's Disease (LOAD) susceptibility in Caucasians. In the present study, we investigated the role of three SNP's in the CDKN2A gene (rs15515, rs3731246, and rs3731211) and one in the CDKN2B gene (rs598664) located in 9p21.3 using an association case-control study carried out in a group of Caucasian subjects including 238 LOAD cases and 250 controls. The role of CDKN2A and CDKN2B genetic variants in AD is not confirmed in our LOAD patients, and further studies are needed to elucidate the role of these genes in the susceptibility of AD.

Association Study of Genetic Variants in CDKN2A/CDKN2B genes/Loci with Late-Onset Alzheimer's Disease / Tedde A; Piaceri I; Bagnoli S; Lucenteforte E; Ueberham U; Arendt T; Sorbi S; Nacmias B.. - In: INTERNATIONAL JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 2090-0252. - ELETTRONICO. - 2011:374631:(2011), pp. 0-0.

Association Study of Genetic Variants in CDKN2A/CDKN2B genes/Loci with Late-Onset Alzheimer's Disease

TEDDE, ANDREA;PIACERI, IRENE;BAGNOLI, SILVIA;Lucenteforte E;SORBI, SANDRO;NACMIAS, BENEDETTA
2011

Abstract

Alzheimer's disease (AD) is the most common form of dementia clinically characterized by progressive impairment of memory and other cognitive functions. Many genetic researches in AD identified one common genetic variant (ε4) in Apolipoprotein E (APOE) gene as a risk factor for the disease. Two independent genome-wide studies demonstrated a new locus on chromosome 9p21.3 implicated in Late-Onset Alzheimer's Disease (LOAD) susceptibility in Caucasians. In the present study, we investigated the role of three SNP's in the CDKN2A gene (rs15515, rs3731246, and rs3731211) and one in the CDKN2B gene (rs598664) located in 9p21.3 using an association case-control study carried out in a group of Caucasian subjects including 238 LOAD cases and 250 controls. The role of CDKN2A and CDKN2B genetic variants in AD is not confirmed in our LOAD patients, and further studies are needed to elucidate the role of these genes in the susceptibility of AD.
2011
2011:374631
0
0
Tedde A; Piaceri I; Bagnoli S; Lucenteforte E; Ueberham U; Arendt T; Sorbi S; Nacmias B.
File in questo prodotto:
File Dimensione Formato  
374631.pdf

accesso aperto

Tipologia: Pdf editoriale (Version of record)
Licenza: Open Access
Dimensione 1.17 MB
Formato Adobe PDF
1.17 MB Adobe PDF

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/597034
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact