Surface-enhanced Raman scattering (SERS) of adenine-containing microRNA chains has been obtained by adsorption on roughened silver substrates. The spectral features of all of these samples appear dominated by the bands of adenine. By comparison with the SERS spectra of adenine and adenosine obtained on the same substrates, along with DFT calculations on the interaction sites of adenine and adenosine with silver, inferences are discussed about the structural arrangement of the microRNA chains with respect to the metal surface. This approach gives suitable guidelines in order to investigate the adsorption of complex biomolecules on metal substrates.

SERS and Computational studies on microRNA chains adsorbed on silver surfaces / M. Muniz-Miranda; C. Gellini; M. Pagliai; M. Innocenti; P.R. Salvi; V. Schettino. - In: JOURNAL OF PHYSICAL CHEMISTRY. C. - ISSN 1932-7447. - STAMPA. - 114:(2010), pp. 13730-13735. [10.1021/jp103304r]

SERS and Computational studies on microRNA chains adsorbed on silver surfaces

MUNIZ-MIRANDA, MAURIZIO;GELLINI, CRISTINA;PAGLIAI, MARCO;INNOCENTI, MASSIMO;SALVI, PIER REMIGIO;SCHETTINO, VINCENZO
2010

Abstract

Surface-enhanced Raman scattering (SERS) of adenine-containing microRNA chains has been obtained by adsorption on roughened silver substrates. The spectral features of all of these samples appear dominated by the bands of adenine. By comparison with the SERS spectra of adenine and adenosine obtained on the same substrates, along with DFT calculations on the interaction sites of adenine and adenosine with silver, inferences are discussed about the structural arrangement of the microRNA chains with respect to the metal surface. This approach gives suitable guidelines in order to investigate the adsorption of complex biomolecules on metal substrates.
2010
114
13730
13735
M. Muniz-Miranda; C. Gellini; M. Pagliai; M. Innocenti; P.R. Salvi; V. Schettino
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/601244
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