Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and anti-inflammatory mechanisms underlying their clinical benefits.
Polyunsaturated fatty acids and cardiovascular disease / Calzolari I;Fumagalli S;Marchionni N;Di Bari M. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - ELETTRONICO. - 15:(2009), pp. 4094-4102. [10.2174/138161209789909755]
Polyunsaturated fatty acids and cardiovascular disease.
FUMAGALLI, STEFANO;MARCHIONNI, NICCOLO';DI BARI, MAURO
2009
Abstract
Several observational and experimental studies show the beneficial effects of ω-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of ω-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of ω-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and anti-inflammatory mechanisms underlying their clinical benefits.
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