In 1996, Wang and his group empirically disclosed a key role of (deoxy)-ATP in functioning of the apoptotic machinery. After almost a decade, and despite the emerged intricacy of the death pathways, ATP is still considered a key determinant of apoptosis with no apparent active roles in necrosis. Yet recent findings indicate that apoptosis proceeds even without energy and that necrosis can be regulated by ATP-dependent processes. This review strictly focuses on current knowledge on the role of energy in execution of different death programs. A thorough understanding of energy requirements in cell death can help to overcome obsolete dogmas in cell biology, paving the way to a more integrated, albeit not simpler, view of the molecular mechanisms contributing to cell dismantling.

"Simple but not simpler": toward a unified picture of energy requirements in cell death / A. Chiarugi. - In: THE FASEB JOURNAL. - ISSN 0892-6638. - STAMPA. - 19:(2005), pp. 1783-1788. [10.1096/fj.05-4200rev]

"Simple but not simpler": toward a unified picture of energy requirements in cell death.

CHIARUGI, ALBERTO
2005

Abstract

In 1996, Wang and his group empirically disclosed a key role of (deoxy)-ATP in functioning of the apoptotic machinery. After almost a decade, and despite the emerged intricacy of the death pathways, ATP is still considered a key determinant of apoptosis with no apparent active roles in necrosis. Yet recent findings indicate that apoptosis proceeds even without energy and that necrosis can be regulated by ATP-dependent processes. This review strictly focuses on current knowledge on the role of energy in execution of different death programs. A thorough understanding of energy requirements in cell death can help to overcome obsolete dogmas in cell biology, paving the way to a more integrated, albeit not simpler, view of the molecular mechanisms contributing to cell dismantling.
2005
19
1783
1788
A. Chiarugi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/606590
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