IN THIS ISSUE, the American Journal of Physiology-Cell Physiology initiates the publication of a new Theme series of review articles that focus on the pathogenic role of ion channels and transporters in cancer. Ion channels, as an important family of membrane proteins that are highly expressed in virtually all types of cells, not only regulate cell excitability, muscle contraction, and glandular secretion. Activity of various ion channels in the plasma membrane and intracellular organelle membranes also plays an important role in regulating cell proliferation, migration, apoptosis and differentiation, cellular functions, and processes that are traditionally considered to be regulated by intracellular signaling proteins and transcription factors. We hope that this series of reviews will bring to readers a new concept regarding the potential role of ion channels in cancer and help provide a rationale for the targeting of ion channels and their chaperones as a new approach for the treatment of cancer.

American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer / A.Arcangeli; JX.Yuan. - In: AMERICAN JOURNAL OF PHYSIOLOGY. - ISSN 1522-1563. - ELETTRONICO. - 301:(2011), pp. 253-254. [10.1152/ajpcell.00159.2011]

American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer.

ARCANGELI, ANNAROSA;
2011

Abstract

IN THIS ISSUE, the American Journal of Physiology-Cell Physiology initiates the publication of a new Theme series of review articles that focus on the pathogenic role of ion channels and transporters in cancer. Ion channels, as an important family of membrane proteins that are highly expressed in virtually all types of cells, not only regulate cell excitability, muscle contraction, and glandular secretion. Activity of various ion channels in the plasma membrane and intracellular organelle membranes also plays an important role in regulating cell proliferation, migration, apoptosis and differentiation, cellular functions, and processes that are traditionally considered to be regulated by intracellular signaling proteins and transcription factors. We hope that this series of reviews will bring to readers a new concept regarding the potential role of ion channels in cancer and help provide a rationale for the targeting of ion channels and their chaperones as a new approach for the treatment of cancer.
301
253
254
A.Arcangeli; JX.Yuan
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/606938
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