Experiments were performed on the chorio-allantoic membrane (CAM) of the chick to evaluate the effects of bombesin (BN) on vascular neoformation. In morphometrical assays, 10-13-10-4 M BN promoted dose-dependent vascular development. Newly formed vessels converged toward the BN release site in a spoked wheel arrangement, suggesting a diffusion gradient mechanism. Structural and ultrastructural analysis of CAM specimens collected near the BN release site showed that both vasculogenetic and angiogenetic processes cooperated in vascular neoformation that involved committed cells from the mesenchyme (angioblasts) as well as endothelial cells. No pattern of vascular development was detected away from the BN release site. Findings from the present study emphasize the role of BN in vascular net development of respiratory organs.

Bombesin promotes vasculogenesis and angiogenesis in chick chorio-allantoic membrane: a morphometric, structural and ultrastructural study / Quagliata S.; Pacini S.; Punzi T.; Malentacchi C.; Ruggiero M.; Delfino G.. - In: JOURNAL OF MORPHOLOGY. - ISSN 0362-2525. - STAMPA. - 269:(2008), pp. 72-83.

Bombesin promotes vasculogenesis and angiogenesis in chick chorio-allantoic membrane: a morphometric, structural and ultrastructural study

PACINI, STEFANIA;DELFINO, GIOVANNI
2008

Abstract

Experiments were performed on the chorio-allantoic membrane (CAM) of the chick to evaluate the effects of bombesin (BN) on vascular neoformation. In morphometrical assays, 10-13-10-4 M BN promoted dose-dependent vascular development. Newly formed vessels converged toward the BN release site in a spoked wheel arrangement, suggesting a diffusion gradient mechanism. Structural and ultrastructural analysis of CAM specimens collected near the BN release site showed that both vasculogenetic and angiogenetic processes cooperated in vascular neoformation that involved committed cells from the mesenchyme (angioblasts) as well as endothelial cells. No pattern of vascular development was detected away from the BN release site. Findings from the present study emphasize the role of BN in vascular net development of respiratory organs.
2008
269
72
83
Quagliata S.; Pacini S.; Punzi T.; Malentacchi C.; Ruggiero M.; Delfino G.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/609023
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