The extraordinary success of imatinib in gastrointestinal stromal tumor (GIST) represents a model for molecularly targeted therapy of solid tumors. Research is currently going to identify the molecular basis of mechanisms of action and drug resistance. For the optimal management of the patients treated, a multidisciplinary approach, including medical oncologists, surgeons, pathologists, and radiologists is needed. In this article, we reviewed recent advances in the clinical management of GIST patients treated with imatinib, and in the knowledge of the molecular mechanisms that are basic to imatinib effects.

Critical update and emerging trends in imatinib treatment for gastrointestinal stromal tumor / U. D. Giorgi;A. Pupi;G. Turrisi;I. Montenora;S. Morini;M. Fayyaz;M. D. Simone;G. Fiorentini. - In: REVIEWS ON RECENT CLINICAL TRIALS. - ISSN 1574-8871. - STAMPA. - 2:(2007), pp. 43-48.

Critical update and emerging trends in imatinib treatment for gastrointestinal stromal tumor.

PUPI, ALBERTO;
2007

Abstract

The extraordinary success of imatinib in gastrointestinal stromal tumor (GIST) represents a model for molecularly targeted therapy of solid tumors. Research is currently going to identify the molecular basis of mechanisms of action and drug resistance. For the optimal management of the patients treated, a multidisciplinary approach, including medical oncologists, surgeons, pathologists, and radiologists is needed. In this article, we reviewed recent advances in the clinical management of GIST patients treated with imatinib, and in the knowledge of the molecular mechanisms that are basic to imatinib effects.
2007
2
43
48
U. D. Giorgi;A. Pupi;G. Turrisi;I. Montenora;S. Morini;M. Fayyaz;M. D. Simone;G. Fiorentini
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/628474
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