Murine neoplastic mast cells which have been loaded with exogenous labelled histamine, released 14C-histamine when exposed to increasing concentrations of phenylephrine and noradrenaline. Adrenaline was only slightly effective, while isoprenaline and dibutyryl-cyclic-AMP were fully inactive. The release of histamine evoked by alpha-adrenergic agonists was antagonized by phentolamine, and left unchanged by practolol and cocaine. It is concluded that alpha-adrenoceptors may be valuable in evoking histamine release by murine neoplastic mast cells.
The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells / F. Moroni;R. Fantozzi;E. Masini;P. F. Mannaioni. - In: AGENTS AND ACTIONS. - ISSN 0065-4299. - STAMPA. - 7:(1977), pp. 57-61.
The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells.
MORONI, FLAVIO;MASINI, EMANUELA;
1977
Abstract
Murine neoplastic mast cells which have been loaded with exogenous labelled histamine, released 14C-histamine when exposed to increasing concentrations of phenylephrine and noradrenaline. Adrenaline was only slightly effective, while isoprenaline and dibutyryl-cyclic-AMP were fully inactive. The release of histamine evoked by alpha-adrenergic agonists was antagonized by phentolamine, and left unchanged by practolol and cocaine. It is concluded that alpha-adrenoceptors may be valuable in evoking histamine release by murine neoplastic mast cells.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.