Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T-->C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE) genotype. No significant association was found for the CYP46 polymorphism in LOAD compared to the controls, even after stratification for the presence/absence of the ApoE*4 allele. Our data do not support a role of the CYP46 polymorphism as a possible susceptibility factor for developing AD.
Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease / Tedde A; Rotondi M; Cellini E; Bagnoli S; Muratore L; Nacmias B; Sorbi S. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - ELETTRONICO. - 27 (5):(2006), pp. 773.e1-773.e3.
Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease
TEDDE, ANDREA;CELLINI, ELENA;BAGNOLI, SILVIA;NACMIAS, BENEDETTA;SORBI, SANDRO
2006
Abstract
Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T-->C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE) genotype. No significant association was found for the CYP46 polymorphism in LOAD compared to the controls, even after stratification for the presence/absence of the ApoE*4 allele. Our data do not support a role of the CYP46 polymorphism as a possible susceptibility factor for developing AD.
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