Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis
Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients / Galimberti S;Guerrini F;Palumbo GA;Consoli U;Fazzi R;Morabito F;Santini V;Petrini M. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 28:(2004), pp. 367-372. [10.1016/j.leukres.2003.09.002]
Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients.
SANTINI, VALERIA;
2004
Abstract
Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis
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