A total of 38 DNA sample pairs from normal and cancerous breasts were specifically examined for alterations on the short arm of chromosome 1 using probe pYNZ2. Of the pairs, 24 (63\%) displayed changes at this locus including amplifications, deletions, gene rearrangements, and altered band intensities between heterozygous alleles. Due to technical considerations, this number is likely to be a conservative estimate of the frequency of alterations in this region. When data using a different probe from the short arm of chromosome 1 was added, the overall involvement of this region increased to 73\%. The combined data indicate we have localized a region, likely to be less than 85 cm in size, that is involved in the development of breast cancer.
Genomic changes on the short arm of human chromosome 1 in breast cancer / W. M. Mars;M. Genuardi;H. Tsihira;D. E. Anderson;G. F. Saunders. - In: CANCER DETECTION AND PREVENTION. - ISSN 0361-090X. - STAMPA. - 15:(1991), pp. 145-149.
Genomic changes on the short arm of human chromosome 1 in breast cancer.
GENUARDI, MAURIZIO;
1991
Abstract
A total of 38 DNA sample pairs from normal and cancerous breasts were specifically examined for alterations on the short arm of chromosome 1 using probe pYNZ2. Of the pairs, 24 (63\%) displayed changes at this locus including amplifications, deletions, gene rearrangements, and altered band intensities between heterozygous alleles. Due to technical considerations, this number is likely to be a conservative estimate of the frequency of alterations in this region. When data using a different probe from the short arm of chromosome 1 was added, the overall involvement of this region increased to 73\%. The combined data indicate we have localized a region, likely to be less than 85 cm in size, that is involved in the development of breast cancer.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.