A total of 38 DNA sample pairs from normal and cancerous breasts were specifically examined for alterations on the short arm of chromosome 1 using probe pYNZ2. Of the pairs, 24 (63\%) displayed changes at this locus including amplifications, deletions, gene rearrangements, and altered band intensities between heterozygous alleles. Due to technical considerations, this number is likely to be a conservative estimate of the frequency of alterations in this region. When data using a different probe from the short arm of chromosome 1 was added, the overall involvement of this region increased to 73\%. The combined data indicate we have localized a region, likely to be less than 85 cm in size, that is involved in the development of breast cancer.

Genomic changes on the short arm of human chromosome 1 in breast cancer / W. M. Mars;M. Genuardi;H. Tsihira;D. E. Anderson;G. F. Saunders. - In: CANCER DETECTION AND PREVENTION. - ISSN 0361-090X. - STAMPA. - 15:(1991), pp. 145-149.

Genomic changes on the short arm of human chromosome 1 in breast cancer.

GENUARDI, MAURIZIO;
1991

Abstract

A total of 38 DNA sample pairs from normal and cancerous breasts were specifically examined for alterations on the short arm of chromosome 1 using probe pYNZ2. Of the pairs, 24 (63\%) displayed changes at this locus including amplifications, deletions, gene rearrangements, and altered band intensities between heterozygous alleles. Due to technical considerations, this number is likely to be a conservative estimate of the frequency of alterations in this region. When data using a different probe from the short arm of chromosome 1 was added, the overall involvement of this region increased to 73\%. The combined data indicate we have localized a region, likely to be less than 85 cm in size, that is involved in the development of breast cancer.
1991
15
145
149
W. M. Mars;M. Genuardi;H. Tsihira;D. E. Anderson;G. F. Saunders
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/649712
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