The PTPN11 gene encodes SHP-2, a widely expressed cytoplasmic protein tyrosine phosphatase functioning as a signaling transducer. Germ-line PTPN11 mutations cause Noonan syndrome (NS), a developmental disorder characterized by an increased risk of malignancies. Recently, a novel class of activating mutations in PTPN11 has been documented as a somatic event in a heterogeneous group of leukemias. Because of the relatively higher prevalence of certain solid tumors in children with NS and the positive modulatory function of SHP-2 in RAS signaling, a wider role for activating PTPN11 mutations in cancer has been hypothesized. Here, we screened a number of solid tumors, including those documented in NS or in which deregulated RAS signaling occurs at significant frequency, for PTPN11 mutations. No disease-associated mutation was identified in rhabdomyosarcoma (n = 13), neuroblastoma (n = 32), melanoma (n = 50), thyroid (n = 85), and colon (n = 48) tumors; a novel missense change, promoting an increased basal phosphatase activity of SHP-2, was observed in one glioma specimen. Our data document that deregulated SHP-2 function does not represent a major molecular event in pediatric and adult tumors, further supporting our previous evidence indicating that the oncogenic role of PTPN11 mutations is cell-context specific.

Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors / S. Martinelli;C. Carta;E. Flex;F. Binni;E. L. Cordisco;S. Moretti;E. Puxeddu;M. Tonacchera;A. Pinchera;H. P. McDowell;C. Dominici;A. Rosolen;C. D. Rocco;R. Riccardi;P. Celli;M. Picardo;M. Genuardi;P. Grammatico;M. Sorcini;M. Tartaglia. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 166:(2006), pp. 124-129. [10.1016/j.cancergencyto.2005.10.003]

Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors.

GENUARDI, MAURIZIO;
2006

Abstract

The PTPN11 gene encodes SHP-2, a widely expressed cytoplasmic protein tyrosine phosphatase functioning as a signaling transducer. Germ-line PTPN11 mutations cause Noonan syndrome (NS), a developmental disorder characterized by an increased risk of malignancies. Recently, a novel class of activating mutations in PTPN11 has been documented as a somatic event in a heterogeneous group of leukemias. Because of the relatively higher prevalence of certain solid tumors in children with NS and the positive modulatory function of SHP-2 in RAS signaling, a wider role for activating PTPN11 mutations in cancer has been hypothesized. Here, we screened a number of solid tumors, including those documented in NS or in which deregulated RAS signaling occurs at significant frequency, for PTPN11 mutations. No disease-associated mutation was identified in rhabdomyosarcoma (n = 13), neuroblastoma (n = 32), melanoma (n = 50), thyroid (n = 85), and colon (n = 48) tumors; a novel missense change, promoting an increased basal phosphatase activity of SHP-2, was observed in one glioma specimen. Our data document that deregulated SHP-2 function does not represent a major molecular event in pediatric and adult tumors, further supporting our previous evidence indicating that the oncogenic role of PTPN11 mutations is cell-context specific.
2006
166
124
129
S. Martinelli;C. Carta;E. Flex;F. Binni;E. L. Cordisco;S. Moretti;E. Puxeddu;M. Tonacchera;A. Pinchera;H. P. McDowell;C. Dominici;A. Rosolen;C. D. Rocco;R. Riccardi;P. Celli;M. Picardo;M. Genuardi;P. Grammatico;M. Sorcini;M. Tartaglia
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/650669
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