Acute brain slice recordings with MEA can provide answers to most of the questions arising along CNS drug development: - Select and optimize hits or lead compounds; MEA recordings can facilitate the screening of a series of compounds in parallel, with a remarkably quick turnaround. - Investigate or confirm compounds’ targets and/or MOA, thanks to a wide panel of tests within a fully physiological context. Very precise pharmacological effects and profiles can thus be determined. - Phenotype transgenic mice or rats for a wide range of neuronal properties and with a minimal number of animals and subsequently determine compound’s target or drug candidate efficacy in these transgenic models. - Clarify compounds’ safety with rapid turnaround and a small quantity of compounds.

Investigating Electrical Network Dynamics in Plant Root Cells by Means of a High-Density CMOS-based Microelectrode Array / E.Masi; M.Fiscella; J.Müller; U.Frey; S.Mancuso; A.Hierlemann. - ELETTRONICO. - (2012), pp. 1-2. (Intervento presentato al convegno 8th International Meeting on Substrate-Integrated Microelectrode Arrays tenutosi a Reutlingen (Germany) nel 11-13 Jul 2012).

Investigating Electrical Network Dynamics in Plant Root Cells by Means of a High-Density CMOS-based Microelectrode Array

MASI, ELISA;MANCUSO, STEFANO;
2012

Abstract

Acute brain slice recordings with MEA can provide answers to most of the questions arising along CNS drug development: - Select and optimize hits or lead compounds; MEA recordings can facilitate the screening of a series of compounds in parallel, with a remarkably quick turnaround. - Investigate or confirm compounds’ targets and/or MOA, thanks to a wide panel of tests within a fully physiological context. Very precise pharmacological effects and profiles can thus be determined. - Phenotype transgenic mice or rats for a wide range of neuronal properties and with a minimal number of animals and subsequently determine compound’s target or drug candidate efficacy in these transgenic models. - Clarify compounds’ safety with rapid turnaround and a small quantity of compounds.
2012
Proceedings MEA Meeting 2012
8th International Meeting on Substrate-Integrated Microelectrode Arrays
Reutlingen (Germany)
11-13 Jul 2012
E.Masi; M.Fiscella; J.Müller; U.Frey; S.Mancuso; A.Hierlemann
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/651728
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