Investigating Electrical Network Dynamics in Plant Root Cells by Means of a High-Density CMOS-based Microelectrode Array

Acute brain slice recordings with MEA can provide answers to most of the questions arising along CNS drug development: - Select and optimize hits or lead compounds; MEA recordings can facilitate the screening of a series of compounds in parallel, with a remarkably quick turnaround. - Investigate or confirm compounds’ targets and/or MOA, thanks to a wide panel of tests within a fully physiological context. Very precise pharmacological effects and profiles can thus be determined. - Phenotype transgenic mice or rats for a wide range of neuronal properties and with a minimal number of animals and subsequently determine compound’s target or drug candidate efficacy in these transgenic models. - Clarify compounds’ safety with rapid turnaround and a small quantity of compounds.