Biochem Biophys Res Commun. 1992 Mar 16;183(2):652-8. Mitogenic signal transduction: a common target for oncogenes that induce resistance to ionizing radiations. Ruggiero M, Casamassima F, Magnelli L, Pacini S, Pierce JH, Greenberger JS, Chiarugi VP. Source Lab. of Mol. Biol., Univ. of Firenze, Italy. Abstract We hypothesized that resistance to ionizing radiations accompanying neoplastic transformation caused by some oncogenes was due to common biochemical pathways affecting the mechanism of mitogenic signal transduction. In order to verify this hypothesis, we studied the formation of mitogenic second messengers in cells transformed by oncogenes that induce radioresistance. We observed an increase of diacylglycerol which activates protein kinase C, an increase of phosphatidylcholine metabolism, with a concomitant decrease of inositol lipid metabolism. Our data show that sensitivity to ionizing radiations was inversely related to the intracellular level of diacylglycerol; study of signalling alterations in spontaneous tumors could provide predictive indications about the responsiveness of neoplasia to radiation therapy. PMID: 1550572 [PubMed - indexed for MEDLINE]
Mitogenic signal transduction: a common target for oncogenes that induce resistance to ionizing radiations / M.Ruggiero; F.Casamassima; L.Magnelli; S.Pacini; JH.Pierce; JS.Greenberger; V. Chiarugi. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 183:(1992), pp. 652-658. [10.1016/0006-291X(92)90532-P]
Mitogenic signal transduction: a common target for oncogenes that induce resistance to ionizing radiations.
RUGGIERO, MARCO;CASAMASSIMA, FRANCO;MAGNELLI, LUCIA;PACINI, STEFANIA;CHIARUGI, VINCENZO
1992
Abstract
Biochem Biophys Res Commun. 1992 Mar 16;183(2):652-8. Mitogenic signal transduction: a common target for oncogenes that induce resistance to ionizing radiations. Ruggiero M, Casamassima F, Magnelli L, Pacini S, Pierce JH, Greenberger JS, Chiarugi VP. Source Lab. of Mol. Biol., Univ. of Firenze, Italy. Abstract We hypothesized that resistance to ionizing radiations accompanying neoplastic transformation caused by some oncogenes was due to common biochemical pathways affecting the mechanism of mitogenic signal transduction. In order to verify this hypothesis, we studied the formation of mitogenic second messengers in cells transformed by oncogenes that induce radioresistance. We observed an increase of diacylglycerol which activates protein kinase C, an increase of phosphatidylcholine metabolism, with a concomitant decrease of inositol lipid metabolism. Our data show that sensitivity to ionizing radiations was inversely related to the intracellular level of diacylglycerol; study of signalling alterations in spontaneous tumors could provide predictive indications about the responsiveness of neoplasia to radiation therapy. PMID: 1550572 [PubMed - indexed for MEDLINE]File | Dimensione | Formato | |
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