Biochem Biophys Res Commun. 1994 Oct 14;204(1):84-90. Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Magnelli L, Cinelli M, Turchetti A, Chiarugi VP. Source Laboratory of Molecular Biology, University of Florence, Italy. Abstract Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events "priming" apoptosis. PMID: 7945396 [PubMed - indexed for MEDLINE]
bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts / L.Magnelli; M.Cinelli; A.Turchetti; V.Chiarugi. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 204:(1994), pp. 84-90. [10.1006/bbrc.1994.2429]
bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts
MAGNELLI, LUCIA;CINELLI, MARINA;CHIARUGI, VINCENZO
1994
Abstract
Biochem Biophys Res Commun. 1994 Oct 14;204(1):84-90. Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Magnelli L, Cinelli M, Turchetti A, Chiarugi VP. Source Laboratory of Molecular Biology, University of Florence, Italy. Abstract Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events "priming" apoptosis. PMID: 7945396 [PubMed - indexed for MEDLINE]
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