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EnglishThe effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.
http://hdl.handle.net/2158/652877| Titolo: | Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects. |
| Autori di Ateneo: | |
| Autori: | A. Cossarizza; MONTI, DANIELA; F. Bersani; R. Paganelli; G. Montagnani; R. Cadossi; M. Cantini; C. Franceschi |
| Anno di registrazione: | 1989 |
| Rivista: | FEBS LETTERS |
| Volume: | 248 |
| Pagina iniziale: | 141 |
| Pagina finale: | 144 |
| Abstract: | The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane. |
| Handle: | http://hdl.handle.net/2158/652877 |
| Appare nelle tipologie: | 1a - Articolo su rivista |
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