Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects.

Cossarizza, A.; Monti, Daniela; Bersani, F.; Paganelli, R.; Montagnani, G.; Cadossi, R.; Cantini, M.; Franceschi, C.

The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.

trova@unifi

Titolo:	Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects.
Autori di Ateneo:	A. Cossarizza MONTI, DANIELA F. Bersani R. Paganelli G. Montagnani R. Cadossi M. Cantini C. Franceschi mostra contributor esterni nascondi contributor esterni
Autori:	A. Cossarizza; MONTI, DANIELA; F. Bersani; R. Paganelli; G. Montagnani; R. Cadossi; M. Cantini; C. Franceschi
Data di pubblicazione:	1989
Rivista:	FEBS LETTERS
Volume:	248
Pagina iniziale:	141
Pagina finale:	144
Abstract:	The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.
Handle:	http://hdl.handle.net/2158/652877
Appare nelle tipologie:	1a - Articolo su rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2158/652877

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.