Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.
LAK activity is inducible in blood mononuclear cells from human fetus / A. Cossarizza;D. Monti;F. Dagna-Bricarelli;G. Montagnani;C. Franceschi. - In: IMMUNOLOGY LETTERS. - ISSN 0165-2478. - STAMPA. - 24:(1990), pp. 137-140.
LAK activity is inducible in blood mononuclear cells from human fetus.
MONTI, DANIELA;
1990
Abstract
Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.