Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.

LAK activity is inducible in blood mononuclear cells from human fetus / A. Cossarizza;D. Monti;F. Dagna-Bricarelli;G. Montagnani;C. Franceschi. - In: IMMUNOLOGY LETTERS. - ISSN 0165-2478. - STAMPA. - 24:(1990), pp. 137-140.

LAK activity is inducible in blood mononuclear cells from human fetus.

MONTI, DANIELA;
1990

Abstract

Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.
1990
24
137
140
A. Cossarizza;D. Monti;F. Dagna-Bricarelli;G. Montagnani;C. Franceschi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/653534
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