Critically ill patients, not infrequently present alterations of physiological parameters that determine the success/failure of therapeutic interventions as well as the final outcome. Sepsis and polytrauma are two of the most common and complex syndromes occurring in Intensive Care Unit (ICU) and affect drug absorption, disposition, metabolism and elimination. Pharmacological management of ICU patients requires consideration of the unique pharmacokinetics associated with these clinical conditions and the likely occurrence of drug interaction. Rational adjustment in drug choice and dosing contributes to the appropriateness of treatment of those patients.

Altered pharmacology in the intensive care unit patient / Giovanni Zagli;Francesca Tarantini;Manuela Bonizzoli;Alessandro Di Filippo;Adriano Peris; De Gaudio R;Pierangelo Geppetti. - In: FUNDAMENTAL & CLINICAL PHARMACOLOGY. - ISSN 0767-3981. - ELETTRONICO. - 22:(2008), pp. 493-501. [10.1111/j.1472-8206.2008.00623.x]

Altered pharmacology in the intensive care unit patient

ZAGLI, GIOVANNI;TARANTINI, FRANCESCA;DI FILIPPO, ALESSANDRO;DE GAUDIO, ANGELO RAFFAELE;GEPPETTI, PIERANGELO
2008

Abstract

Critically ill patients, not infrequently present alterations of physiological parameters that determine the success/failure of therapeutic interventions as well as the final outcome. Sepsis and polytrauma are two of the most common and complex syndromes occurring in Intensive Care Unit (ICU) and affect drug absorption, disposition, metabolism and elimination. Pharmacological management of ICU patients requires consideration of the unique pharmacokinetics associated with these clinical conditions and the likely occurrence of drug interaction. Rational adjustment in drug choice and dosing contributes to the appropriateness of treatment of those patients.
2008
22
493
501
Giovanni Zagli;Francesca Tarantini;Manuela Bonizzoli;Alessandro Di Filippo;Adriano Peris; De Gaudio R;Pierangelo Geppetti
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/654887
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